These microdose capsules are a cheaper alternative to our microdose liquid and microdose gummies. Just as easy to dose as the gummies, these capsules are made using our Amazonian Cubensis. We grind the mushrooms into a fine powder before measuring the precise amount required for a microdose. We add 50mg of ginger to each capsule to help with any stomach discomfort. We offer two strengths, just like our gummies. “Micro” dose (125mg) for the average user, and “Low” dose (250mg) for the experienced user, or for those who need a higher dose. Each bottle contains 30 capsules.
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- Many people who experience depression do not find relief through psychotherapy or existing medications.
- A new study found that psilocybin can be highly effective in relieving depression.
- The relative safety and efficacy of psilocybin suggest that it could be a powerful way to treat depression.
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There is an urgent need for effective depression treatments for the 21 million adults in the US (8 percent) who experience depression each year; the numbers are even higher for females (over 10 percent) and people 18 to 25 years of age (over 18 percent). In addition to the suffering depression causes, it often leads to major life disruptions, such as missed work, strained relationships, and substance use disorders.
Well-established treatments for depression include psychotherapy and medications such as fluoxetine (Prozac). However, even the best-tested drugs and therapies help only about 60 percent of those who receive them. Additionally, many people on existing medication experience unwelcome side effects, such as headaches, emotional numbing, and the inability to reach orgasm, and the medications are often prescribed indefinitely.
In this context, there has been a lot of enthusiasm for the potential role of psychedelics in treating depression. A recent study in JAMA, the top medical journal in the US, found that psilocybin (the active ingredient in so-called “magic mushrooms”) could provide rapid relief.
A large team of researchers across 11 sites in the US recruited 104 participants with mild to moderate depression. They excluded people with a history of psychosis or mania, more than a mild current substance use problem, and active suicidal intent. Those on medication for depression gradually tapered off the drug before the treatment phase of the study.
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Participants were randomly assigned to receive either a synthetic form of psilocybin (51 people) or niacin, the control condition (53). The control allowed researchers to see whether psilocybin had an effect beyond the placebo response, which tends to be strong in depression treatment; niacin was chosen because the acute physiological response it causes (flushing) would make it harder for participants to know for sure which treatment they had received.
Trained facilitators guided all participants through a 7- to 10-hour session in which they received their dose of either niacin or psilocybin; both participants and facilitators were blind to treatment condition to isolate the actual treatment effect, versus the expectancies of those involved. The clinicians who evaluated participants’ depression symptoms and other variables were also blind to the treatment condition.
Does Psilocybin Work for depression?
The psilocybin group had a much greater drop in depression symptoms than the control group, both at 8 days following treatment — 50% reduction in symptoms vs. 17% for the niacin group — and at 6-week follow-up: 54% vs. 19%. Interestingly, the vast majority of the improvement happened by Day 8.
Those who received psilocybin also reported a significantly larger improvement in their disability scores across the follow-up period — 61% vs. 25% — showing that the greater symptom relief led to more improvement in functioning.
A greater number of participants in the psilocybin group experienced treatment-related adverse events (82%) compared to the control group (44%). Most of these events were known effects of psilocybin; the most commonly reported were headache, nausea, and visual perceptual effects, which were mostly limited to the period when participants were experiencing the acute effects of the drug. No suicide attempts or self-injury occurred in either group. In contrast to typical medications for depression, psilocybin did not lead to emotional blunting.
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How Does Psilocybin Work?
It’s remarkable that a single dose of a drug can produce such powerful effects on depression—especially among a group of people who had been depressed for just over a year, on average. Matt Zemon, an expert on the therapeutic use of psychedelics and editor of Psychedelics for Everyone, offers three likely explanations:
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